Postdoctoral Research Fellow - Cardiometabolic Disease

Merck & Co., Inc.

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Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

Be a part of the legacy: MRL Postdoctoral Research Fellow Program.

The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

 

Glucagon has been known for many years to have positive effects on cholesterol lowering. In addition, recent disclosures of clinical studies with compounds that antagonize the glucagon receptor (GRAs) have suggested that, despite very promising effects on glucose, blocking the metabolic actions of glucagon may exacerbate dyslipidemia in these patients. It is therefore a conundrum why endogenous glucagon levels are frequently elevated in diabetics, yet the potential cholesterol regulating aspects of this mechanism are not apparent. As a postdoctoral fellow in the Cardiometabolic Disease department you will work with a highly collaborative team of scientists from Cardiometabolic Disease basic research and in vitro and in vivo pharmacology to conceive, design, plan and implement experiments designed to establish the role of hyperglucagonemia in dyslipidemia and Type 2 Diabetes.

Responsibilities include but are not limited to: 

• Leading the development and implementation of assays and protocols.
• Designing and leading rodent in vivo studies.

Education Minimum Requirement:

• PhD in Diabetes, Cardiovascular disease or a related area

Required Experience and Skills:

• PhD, or met all the requirements for a PhD by June 2015, with 3 years or less postdoctoral experience
• Experience in in vitro assay development and innovation
• Experience in in vivo model pharmacology
• Knowledge of diabetes or lipid biology
• Experience in biochemistry, molecular biology or cell biology

Preferred Experience and Skills:

• Experience with in vivo labeled tracer studies
• Experience with Taqman, PCR and Western Blot techniques
• Experience with culturing primary hepatocytes

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service. 
 

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