Postdoctoral Research Fellow - Biology

Merck & Co., Inc.

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Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

Be a part of the legacy: MRL Postdoctoral Research Fellow Program.

The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

The primary goal of this project is to gain a mechanistic understanding of the cellular and molecular mechanisms governing the fate and activity profile of multi-specific antibody modalities. This project will generate a novel systematic and mechanistic framework highly relevant and critical for successful design, selection and development of the next generation antibody-based therapeutics in MRL biologics pipeline.

Responsibilities include but are not limited to:

• Develop proficiency in all relevant in-house experimental in vitro and in vivo procedures including labeling techniques, use of specific tools, laboratory equipment, recombinant DNA technology, data gathering and analytical programs.
• Assessment of pharmacokinetic, metabolism and biodistributional properties (target-independent) and the impact of target/s expression on the fate of selected experimental constructs in relevant preclinical models.
• Evaluation of in vivo pharmacological activity profiles in relevant disease models with inclusion of appropriate design and controls to evaluate the synergistic activity properties of the multi-specific constructs in comparison to the relevant single agent and combination controls.

Education Minimum Requirement:

• PhD in Biological Sciences

Required Experience and Skills:

• PhD, or met all the requirements for a PhD by June 2015, with 3 years or less postdoctoral experience.
• Experience with in vivo models in the following therapy areas: Infectious disease, Immunology.
• Advanced cell and tissue culture skills, including growth of immune cells and T-cells.
• Able to perform cellular immune function assays (i.e. proliferation/cytotoxicity/apoptosis assays).
• Proficient in cell separation techniques and preparation for FACS sorting with strong experience in FACS analysis.

Preferred Experience and Skills:

• Molecular biology, protein expression, purification, labeling techniques
• Cell line engineering for assay development
• Strong history of publication in peer-reviewed journals

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service.

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